Adding a certain compound to certain chemical reactions, such as: 58481-11-1, Methyl 2-chloroisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 58481-11-1, blongs to pyridine-derivatives compound. Recommanded Product: Methyl 2-chloroisonicotinate
To a stirred solution of methyl 2chloro isonicotinate (2 g, 0.012 mol) in toluene (20 mL) was added hexamethylditin (4.5 g, 0.014 mol), the mixture was degassed with argon for 10 minutes, then Pd(PPh3)4 (1.35 g, 0001 mol) was added, the mixture was degassed again for 5 minutes and the resulting reaction mixture was heated at 110¡ãC for 16h. The progress of the reaction was monitored by LCMS. The reaction mixture was cooled to RT, filtered through the Celite pad, washed with EtOAc and the filtrate was concentrated to get acrude compound. The crude compound was purified by column chromatography using neutral alumina and eluted with 5percentEtOAc/pet ether to afford the title compound (1.5 g, 42percent) as a colorless liquid.LCMS (method 1): R = 1.20 mm; m/z = 301 .99(M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58481-11-1, its application will become more common.
Reference:
Patent; ORYZON GENOMICS, S.A.; ORTEGA MUNOZ, Alberto; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; (176 pag.)WO2017/207813; (2017); A1;,
Pyridine – Wikipedia,
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