Adding a certain compound to certain chemical reactions, such as: 59290-81-2, 2-Methyl-5-nitro-3-pyridinecarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 59290-81-2, blongs to pyridine-derivatives compound. SDS of cas: 59290-81-2
4-(Pyridin-2-ylmethoxy)-phenylamine (0.4 mmol), prepared as described for intermediate II, was coupled with 1 (72 mg, 0.4 mmol) in 4 ml DCM and 1 ml DMF in the presence of PyBOP (416 mg, 0.8 mmol) and DIEA (204 mul, 1.2 mmol). After stirring overnight at r.t, the reaction mixture was diluted with DCM, and washed with aq. NaHCO3. The DCM phase was concentrated, the residue was dissolved in DMF and then subjected to preparative HPLC purification. The target product (173 mg) was obtained as an off white solid. (Calculated mass: 364.3, observed mass: 364.5).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,59290-81-2, 2-Methyl-5-nitro-3-pyridinecarboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; KEMIA, INC.; WO2007/56016; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem