Adding a certain compound to certain chemical reactions, such as: 582325-22-2, 6-(3-Fluorophenyl)nicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H8FNO2, blongs to pyridine-derivatives compound. Formula: C12H8FNO2
To a vial was added, 6-(3-fluorophenyl)nicotinic acid (46.4 mg, 0.213 mmol), 1-(7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)piperidin-4-amine (50 mg, 0.21 mmol), EDAC (45.0 mg, 0.235 mmol), HOBT (28.8 mg, 0.213 mmol), and DMA (1 mL) followed by NMM (0.058 mL, 0.534 mmol). The reaction was stirred overnight at room temperature and then diluted with H20 and the resulting solid filtered and collected to give the desired product, N-(1-{5-[(2,5-dimethyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]pyridin-2-yl}piperidin-4-yl)-6-(3-fluorophenyl)nicotinamide (81 mg, 88%). 1H NMR (400 MHz, DMSO-d6) ppm 9.06 (1 H, s), 8.45 (1 H, d, J=7.5 Hz), 8.21-8.30 (1 H, m), 8.04-8.14 (2 H, m), 7.89-8.02 (2H, m) 7.49-7.59 (1 H, m), 7.29 (1 H, t), 4.49-4.64 (5 H, m), 4.11 (1 H, br. s.), 3.89 (2 H, t, J=5.9 Hz), 2.94-3.07 (2 H, m), 1.88 (2 H, d, J=10.1 Hz), 1.42-1.56 (3 H, m). HRMS (TOF, ES+) calculated for M+H: 434.1992; observed 434.2165.
The synthetic route of 582325-22-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Blake, Tanisha D.; Hamper, Bruce C.; Huang, Wei; Kiefer, James R.; Moon, Joseph B.; Neal, Bradley E.; Olson, Kirk L.; Pelc, Matthew J.; Schweitzer, Barbara A.; Thorarensen, Atli; Trujillo, John I.; Turner, Steven R.; US2008/146569; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem