With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.159307-02-5, name is 6-Acetylpicolinonitrile, molecular formula is C8H6N2O, molecular weight is 146.15, as common compound, the synthetic route is as follows.Application In Synthesis of 6-Acetylpicolinonitrile
Compound 4b:to 100 ml by adding three-necked bottle of 2-cyano-6-acetyl-pyridine (3.00g, 20 . 53mmol), 2,6-dimethyl aniline (2.74g, 22 . 58mmol), the toluene sulphonic acid monohydrate (195 mg, 1 . 03mmol), solvent toluene and 50 ml, reflux device installed, heating reaction refluxing 48h. Cooling to room temperature, vacuum concentration, rapid column chromatography purification (ethyl acetate: petroleum ether = 1:20), to get the yellow oily matter (5.04g, 96%),
At the same time, in my other blogs, there are other synthetic methods of this type of compound,159307-02-5, 6-Acetylpicolinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Institute of Organic Chemistry; Huang, Zheng; Zuo, Ziqing; Zhang, Lei; (50 pag.)CN105294667; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem