With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73895-98-4, name is 6-Bromo-4-methylpyridin-2-amine, molecular formula is C6H7BrN2, molecular weight is 187.04, as common compound, the synthetic route is as follows.SDS of cas: 73895-98-4
This compound was forwarded to the next step without further purification. To a stirred solution of 6-amino-2-bromo-4-methylpyridine (45.2 g; 0.24 mol) in 100 ml water and 43 g concentrated sulphuric acid at ice-bath temperature was given a solution of sodium nitrite (13.2 g; 0.19 mol) in 20 ml water. After 2 hours the reaction mixture was warmed to 60 C. and stirred for further 60 minutes. After cooling, the mixture was extracted with 200 ml of dichloromethane. The solvent was removed in vacuo and 2-bromo-4-methyl-6-hydroxypyridine (20 g, 56%) was obtained as colourless crystals of melting point 152 C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,73895-98-4, 6-Bromo-4-methylpyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; American Cyanamid Company; US5840654; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem