Application of 898746-42-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 898746-42-4, name is 6-Fluoro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation 17Synthesis of l-cyclopropyl-6-fluoro-lH-pyrrolo[2,3-b]pyridine.To a solution of 6-fluoro-lH-pyrrolo[2,3-b]pyridine (6.2 g, 45.55 mmol) in dryDCM (250 mL) is added cyclopropylboronic acid (7.82 g, 91.09 mmol), followed by cupric acetate (8.36 g, 45.55 mmol), sodium carbonate (9.65 g, 91.09 mmol) and 2,2′- bipyridine (7.1 1 g, 45.55 mmol). The resulting mixture is stirred and heated at 50C for 15h. The mixture is cooled to room temperature and further cupric acetate (4.18 g, 22.77 mmol) and sodium carbonate (2.41 g, 22.77 mmol) are added, followed bycyclopropylboronic acid (1.96 g, 22.77 mmol). The mixture is stirred and heated at 50C for a further 15h when further cupric acetate (1.5 g, 8.25 mmol) and cyclopropylboronic acid (1.49 g, 17.34 mmol) are added. The mixture is stirred at room temperature for 4 days and then poured onto sat. aq. NH4C1, diluted with water and extracted with DCM. The organic layers are combined, washed with brine, dried (magnesium sulphate) and concentrated in vacuo to give a green oil, which is purified by column chromatography on silica, eluting with DCM, to give the title compound (2.03 g, 11.52 mmol). MS (m/z): 177 (M+l). Unreacted 6-fluoro-lH-pyrrolo[2,3-b]pyridine is also recovered (3.012g, 22.1 mmol). MS (m/z): 137 (M+l).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 898746-42-4, 6-Fluoro-1H-pyrrolo[2,3-b]pyridine.
Reference:
Patent; ELI LILLY AND COMPANY; LAMAS-PETEIRA, Carlos; RICHARDS, Simon, James; SAPMAZ, Selma; WALTER, Magnus, Wilhelm; WO2012/74769; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem