Related Products of 614750-81-1 ,Some common heterocyclic compound, 614750-81-1, molecular formula is C7H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a stirred solution of[1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde(1.77 g, 12.04 mmol) in a mixture of THF (48 mL) and i-PrOH (12 mL), 13a, 13b, or 13c (5.40 g, 12.04 mmol) and Cs2CO3 (5.10 g, 15.65mmol) were added. The mixture was stirred at room temperature for 24 h, and toit, 3 N HCl (20 mL) was added dropwise and stirred for an additional 1 h. Thereaction mixture was diluted with tert-butylmethyl ether (50 mL) and extracted with 1 N HCl (2 ¡Á 50 mL). The combined aqueous layer was neutralizedwith 2 N NaOH at 0 oC while a lot of yellow precipitates wereformed. The mixture was stirred at 0 oC for an additional 2 h andthen filtered. The filtered precipitates were washed with water (2 ¡Á 50 mL), and the solid was dissolved in CH2Cl2(200 mL). The CH2Cl2 solution was washed with brine (50mL), dried over anhydrous Na2SO4, filtered, and then evaporatedto dryness under reduced pressure to afford the titled compounds as an off-whitesolid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 614750-81-1, [1,2,4]Triazolo[1,5-a]pyridine-6-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Krishnaiah, Maddeboina; Jin, Cheng Hua; Sheen, Yhun Yhong; Kim, Dae-Kee; Bioorganic and Medicinal Chemistry Letters; vol. 25; 22; (2015); p. 5228 – 5231;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem