Adding a certain compound to certain chemical reactions, such as: 62150-47-4, Ethyl 4-bromopicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 62150-47-4, blongs to pyridine-derivatives compound. Product Details of 62150-47-4
A solution of ethyl 4-bromo-2-picolinate (1e) (92%, 20.6 g, 82.3 mmol) and acetone (2.43 mL, 32.9 mmol) in DME (100 mL) was added dropwise to a stirred suspension of NaH (60% suspension in oil, 6.6 g, 165 mmol) in DME (100 mL) under an atmosphere of argon at room temperature. The temperature was slowly increased until reflux was achieved, and a vigorous evolution of gas was observed after 10 min and the brown suspension turned dark red. The reaction mixture was allowed to cool to room temperature and was stirred for 2 h. The solvent was removed in vacuo and the red-orange paste slowly treated with water (200 mL). The resultant insoluble mixture was acidified as described in previously to pH 6.5 and the copious amount of yellow solid so obtained was collected by filtration and washed with water until the washing appeared colourless. The solid was oven-dried under vacuum (40C, ca. 30 mm) for 2 days to yield the crude triketone 5e as a yellow solid (15.3 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62150-47-4, its application will become more common.
Reference:
Article; Lin, Chih-Pei; Florio, Pas; Campi, Eva M.; Zhang, Chunfang; Fredericks, Dale P.; Saito, Kei; Jackson, W. Roy; Hearn, Milton T.W.; Tetrahedron; vol. 70; 45; (2014); p. 8520 – 8531;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem