In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-64-2, name is Pyridin-4-ol, the common compound, a new synthetic route is introduced below. 626-64-2
A solution of an alcohol (0.4 mmol), a phenol/thiophenol (0.4 mmol), diisopro-pylethylamin (0.44 mmol) and tributylphosphine (0.52 mmol) in THF (5 mL) was stirred undernitrogen at rt. 1,1′-(Azodicarbonyl)dipiperidine (ADDP, 0.52 mmol) dissolved in THF (5 mL)was added and the reaction mixture was stirred at rt for 16 h. The reaction mixture was fil- tered and the filtrate was evaporated to dryness, which gave a crude which was either puri- fied by flash chromatography (Quad flash 25, EtOAc-heptane) or redissolved in MeCN andpurified by preparative HPLC (Gilson).Example 1 (General procedure 1)Methyl-phenyl-carbamic acid 4-[2-(pyridin-4-yloxy)-ethyl]-phenyl esterThe title compound (99%) was prepared as an oil using methyl-phenyl-carbamic acid 4-(2-hydroxy-ethyl)-phenyl ester and 4-hydroxypyridine.HPLC-MS : mlz = 349.2 (M+1); R, = 2.64 min.
Statistics shows that 626-64-2 is playing an increasingly important role. we look forward to future research findings about Pyridin-4-ol.
Reference:
Patent; NOVO NORDISK A/S; WO2004/111006; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem