As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6274-82-4, name is 2,6-Dimethoxyisonicotinic acid, molecular formula is C8H9NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 6274-82-4
General procedure: 4.1.2.1. General synthetic procedure for preparation of diarylketones(Procedure 1). 1 equivalent of nBuLi (1.6 M in hexane) was addedonto a solution of bromoderivative completely dissolved in dry THF at-40 C. After one hour stirring, 0.4 equivalents of carboxylic aciddissolved in dry THF was added and the mixture was warmed to roomtemperature. After 24 h, ethyl formate, ethyl acetate and water wereadded. The organic phase was partially evaporated, washed with brine,dried over Na2SO4, filtered and evaporated to dryness. The productsobtained were purified by flash chromatography.
With the rapid development of chemical substances, we look forward to future research findings about 6274-82-4.
Reference:
Article; Aramburu, Laura; Gajate, Consuelo; Medarde, Manuel; Mollinedo, Faustino; Alvarez, Raquel; Pelaez, Rafael; Vicente-Blazquez, Alba; Bioorganic Chemistry; vol. 98; (2020);,
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