6419-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 1-Preparation of risedronic acid A mixture of (3-pyridyl) acetic acid hydrochloride (10 g 0.06 moles) and phosphorous acid (47 g, 0.58 moles) is slowly added with phosphorus oxychloride (28.8 g 0.19 moles). The fluid mixture is warmed up to 60-70C for 24 hours, then added with 60 ml water at the same temperature. The mixture is refluxed for 6 hours, added with 0.3 g charcoal and hot-filtered through celite. The clarified solution is added with 160 ml acetone. The resulting precipitate is filtered, suspended in 50 ml water, dissolved at pH 7.5 (+/-0.2) with 30% sodium hydroxide. The resulting solution is acidified to pH 0.8 (+/-0. 2) and the precipitate is filtered and dried under vacuum at 40-50C to constant weight. 9. 8 g pure risedronic acid is obtained (yield: 60%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6419-36-9, 2-(Pyridin-3-yl)acetic acid hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LYOGEN LIMITED; WO2005/63779; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem