In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, the common compound, a new synthetic route is introduced below. Computed Properties of C8H10ClNO3
General procedure: To a solution of pyridoxal hydrochloride 5 (2.0 mmol, 0.40 g) in water (1 mL) was added the corresponding chromone 6 (2.0 mmol) in methanol (2-10 mL) and NaOH (5.2 mmol, 0.21 g). The reaction mixture was stirred at 50 C for 4-6 h, cooled to ?20 C and allowed to stand at room temperature for 18-36 h (for 6d: ?20 C, 4 h). The resulting mixture was diluted with water (10 mL) and neutralized with HCl to pH 7. The solid that formed was filtered, washed with water, dried, and recrystallized from methanol to give product 7 as an orange powder.
The synthetic route of 65-22-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sosnovskikh, Vyacheslav Ya; Korotaev, Vladislav Yu.; Barkov, Alexey Yu.; Sokovnina, Anna A.; Kodess, Mikhail I.; Journal of Fluorine Chemistry; vol. 141; (2012); p. 58 – 63;,
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