Application of 76006-11-6 ,Some common heterocyclic compound, 76006-11-6, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Chloro derivative 6 (490 mg, 3.19 mmol) was dissolved into concentrated sulfuric acid (9.50 mL) at 0C and then a mixture ofconcentrated sulfuric acid (0.49 mL) and nitric acid (0.49 mL)was added dropwise into this solution. This reaction mixturewas heated at 95C for 1h. Upon cooling, it was poured intocrashed ice, neutralized with an aqueous solution of NH3 andthe product was extracted with ethyl acetate (3×100 mL). Thecombined organic layers were dried over Na2SO4 and evaporated under reduced pressure to provide 600 mg of pure 7 asa yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 76006-11-6, 7-Chloro-1H-pyrazolo[3,4-c]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Sklepari, Meropi; Lougiakis, Nikolaos; Papastathopoulos, Athanasios; Pouli, Nicole; Marakos, Panagiotis; Myrianthopoulos, Vassilios; Robert, Thomas; Bach, Stephane; Mikros, Emmanuel; Ruchaud, Sandrine; Chemical and Pharmaceutical Bulletin; vol. 65; 1; (2017); p. 66 – 81;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem