Adding a certain compound to certain chemical reactions, such as: 74420-15-8, 3-Bromo-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
General procedure: In a dry and argon flushed 10 mL Schlenk tube, equipped with a magnetic stirring bar and a septum, Pd(O2CCF3)2 (7 mg, 2 mol%) was dissolvedin anhydrous THF (1 mL). Then, SPhos (16 mg, 4 mol%) was added and the reaction mixture was stirred at r.t. for 10 min, beforethe 3-bromo-7-azaindole (9a; 158 mg, 0.8 mmol, 1.0 equiv) and the previously zincated ester derivative 6 (1.3 mmol, 1.6 equiv) were added subsequently. The mixture was stirred at 50 C for the indicated time. The completion of the reaction was checked by GC analysis of reaction aliquots quenched with H2O (0.5 mL). The mixture was then quenched with a sat. aq NH4Cl (3 mL) and extracted with EtOAc(3 ¡Á 10 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo. The crude products 4a and 4b were purifiedby flash chromatography
The synthetic route of 74420-15-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Barl, Nadja M.; Malakhov, Vladimir; Mathes, Christian; Lustenberger, Philipp; Knochel, Paul; Synthesis; vol. 47; 5; (2015); p. 692 – 700;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem