Application of 7598-35-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7598-35-8, name is 2-Bromopyridin-4-amine. A new synthetic method of this compound is introduced below.
To a cooled (0 C.) solution of 2-bromo-4-aminopyridine (295 mg, 1.5 mmol) in dry DMF (5 ml) was added NaH (120 mg, 3.0 mmol, 60% dispersion in mineral oil) carefully. The mixture was stirred at room temperature for 30 min and then cooled to 0 C. again. A solution of the acid chloride from the preceeding step in dry DMF (5 ml) was added into the mixture slowly. The resulting mixture was stirred for an additional hour at room temperature and then quenched with ice-water (20 ml). The mixture was extracted with ethyl acetate (3¡Á50 ml). The combined organic extracts were washed with brine (20 mL), dried over MgSO4 and concentrated under reduced pressure. The residue was purified by flash chromatography (ethyl acetate/petroleum ether=1:10) to give N-(2-bromopyridin-4-yl)-2,6-dichloro-4-cyanobenzamide (389 mg, 70% yield). LCMS (ESI) m/z: 369.9 [M+H+].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7598-35-8, 2-Bromopyridin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; GENENTECH, INC.; US2010/317643; (2010); A1;,
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