Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 851386-40-8, name is 4-Chloro-2,5-difluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. name: 4-Chloro-2,5-difluoropyridine
To a solution of 4-chloro-2,5-difluoropyridine (200 nig, 1.33 mmol) and 4M HCl in dioxane (0.33 ml, 1.33 mmol) in 2-propanol (3 ml) was added hydrazine hydrate (134 mg, 2.68 mmol). Reaction mixture was stirred at rt for 1 month. Solvents were evaporated under vacuum. Aqueous NaHC03 solution was added to the mixture. Precipitate formed was filtered oft” washed with water and dried under vacuum yielding 51 mg of 4-chloro-5- fluoro-2-hydrazinylpyridine and 2,5-difluoro-4-hydrazinylpyridine as a 1/1 mixture.MS: m/z 162 I M I f ] . 1H NMR (DMSO-d6) delta: 8. 19 (br s, IH), 8.09 (d, 1 1 1 ).. 7.70 (d, 1 1 1 }.. 7.66 (d, H), 6.88 (d, IH), 6.55 (d, IH), 4.39 (d, 2H), 4.21 (br s, 2H )
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Reference:
Patent; RICHTER GEDEON NYRT.; ORION CORPORATION; HAIKARAINEN, Anssi; JOUBERT, Muriel; KAROLYI, Benedek; KAeSNAeNEN, Heikki; PASSINIEMI, Mikko; POHJAKALLIO, Antti; SZANTO, Gabor; VAISMAA, Matti; (97 pag.)WO2019/43635; (2019); A1;,
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