With the rapid development of chemical substances, we look forward to future research findings about 87407-12-3.
The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87407-12-3, name is 3-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-(Trifluoromethyl)picolinic acid
Example 122; N- [3- ({2-[ (cyclopropylcarbonyl) amino] imidazo [1, 2-a] pyridin-6- yl}oxy) phenyl] -3- (trifluoromethyl) pyridine-2-carboxamide; To a solution of 3- (trifluoromethyl)pyridine-2-carboxylic acid (47.5 mg, 0.249 mmol) in tetrahydrofuran (5 mL) were addedN,N-dimethylformamide (2 drops) and oxalyl chloride (43.2 muL, 0.498 mmol), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure, the residue was dissolved in N,N-dimethylacetamide (6 mL) , and the solution was stirred at room temperature. N- [6- (3- Aminophenoxy) imidazo [1, 2-a]pyridin-2-yl] cyclopropanecarboxamide (66 mg, 0.214 mmol) was added thereto, and the mixture was stirred at room temperature for 3 days. The reaction mixture was diluted with aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (0%-?-100% ethyl acetate-hexane) to give the title compound (72.5 mg, 70%) as a white solid. 1H-NMR (DMSO-d6,400 MHz) delta 0.74 – 0.85 (4H, m) , 1.87 – 1.98 (IH, m) , 6.81 (IH, dd, J = 8.3, 2.4 Hz), 7.12 (IH, dd, J = 9.7, 2.3 Hz), 7.32 – 7.40 (2H, m) , 7.48 (IH, d, J = 9.5 Hz), 7.54 (IH, d, J = 8.1 Hz), 7.80 (IH, dd, J = 8.3, 4.9 Hz), 8.07 (IH, s) , 8.38 (IH, d, J = 7.8 Hz), 8.61 (IH, d, J = 2.2 Hz), 8.91 (IH, d, J = 4.4 Hz), 10.78 (IH, s) , 10.99 (IH, s) .
With the rapid development of chemical substances, we look forward to future research findings about 87407-12-3.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/150015; (2008); A1;,
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