88150-62-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88150-62-3, name is Phthaloylamlodipine, the common compound, a new synthetic route is introduced below.
Preparation of 3-Ethyl 5-methyl (4RS)-4-(2-CHLOROPHENYL)- [2-L [2-METHYLCARBAMOYL) BENZOYLSAMINO] ethoxy]methyl]-1, 4-dihydropyridine-3, 5-dicarboxylate (VII) A 250 ML one-necked flask, equipped with a magnetic stirrer was charged with 10 g phthaloyl amlodipine in 25 ML of THF. To this solution was added 3 mL of methyamine (40%). The solution was stirred at rt for 30 minutes. The solvent was evaporated in vacuo. The residue was precipitated by adding diethylether to give the title compound as a white solid 9.72 g (92%, with a relative purity> 96% based on AREA%). IR (cm-1) : 3340,2341, 1699, 1670,1636, 1540,1487, 1286,1205, 1100,870, 668. EI-MS (70 eV) : 569 + (3), 538 [M- C2H5] +(12), 458 [M-C6H5C1] + (45), 427 [M-C6H4CI-OME] + (91), 347 [CISHJSCINC (100), 297 (66), 280 (7), 260 (13), 254 (18), 236 [CL2HL5N207] + (10), 223 [C11H14N2O3]+ (28), 208 (57), 174 (61), 162 (71), 148 (12), 130 (14), 105 (10), 76 (8). 1H-NMR (CDCL3) 6 7.83 (d, 1H), 7.63-7. 67 (m, 2H), 7.41-7. 45 (M, 2H), 7.36 (d, 1H), 7.20 (d, 1H), 7.10 (q, 1H), 7.00 (Q, 1H), 6.90 (q, 1H), 5.37 (s, 1H), 4. 77 (d, 1H), 4.67 (d, 1H), 4.03 (q, 2H), 3.80-3. 82 (m, 2H), 3.61-3. 66 (m, 2H), 3. 57 (s, 3H), 2.91 (d, 3H), 2. 30 (s, 3H), 1.16 (t, 3H). 13C-NMR (CDCL3) 8 170.9, 168. 9, 168.3, 167.4, 146.1, 145.2, 145.1, 134.8, 134.2, 132. 4,131. 6,130. 3,129. 5, 129.4, 127.9, 127.5, 127.0, 103.7, 101.9, 70.4, 70.3, 60.0, 50. 9, 39. 8, 37. 2,27. 2,19. 2,14. 4.
Statistics shows that 88150-62-3 is playing an increasingly important role. we look forward to future research findings about Phthaloylamlodipine.
Reference:
Patent; EOS ECZACIBASI OZGUN KIMYASAL URUNLER SANAYI VE TICARET A.S.; WO2004/58711; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem