Adding a certain compound to certain chemical reactions, such as: 912934-77-1, 6-Bromopyridine-2-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 6-Bromopyridine-2-sulfonyl chloride, blongs to pyridine-derivatives compound. name: 6-Bromopyridine-2-sulfonyl chloride
Step 1-Preparation of 1-((6-bromopyridin-2-yl)sulfonyl)pyrrolidine-3-carbonitrile, 64 To 6-bromopyridine-2-sulfonyl chloride (100 mg, 0.39 mmol) was added pyrrolidine-3-carbonitrile (37.48 mg, 0.39 mmol) and dichloromethane (2 ml). The reaction was allowed to stir at room temperature for 30 minutes. The reaction was quenched with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to dryness to provide 1-((6-bromopyridin-2-yl)sulfonyl)pyrrolidine-3-carbonitrile 64. This material was used in the next step without further purification.
The synthetic route of 912934-77-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Plexxikon Inc.; Wu, Guoxian; Wu, Jeffrey; Chan, Katrina; Dong, Ken; Ewing, Todd; Ibrahim, Prabha N.; Lin, Jack; Spevak, Wayne; Zhang, Ying; (150 pag.)US2017/158690; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem