Authors Bregier, F; Godard, J; Thiais, J; Bouramtane, S; Moulin, A; Champavier, Y; Mailleau, A; Chaleix, V; Sol, V in WORLD SCI PUBL CO INC published article about PHOTODYNAMIC THERAPY; STANNOUS CHLORIDE; DERIVATIVES; SUBSTITUENTS; AGENTS; PDT in [Bregier, Frederique; Godard, Jeremy; Thiais, Jordan; Bouramtane, Soukaina; Moulin, Alexia; Chaleix, Vincent; Sol, Vincent] Univ Limoges, PEIRENE, EA 7500, 123 Ave Albert Thomas, F-87060 Limoges, France; [Champavier, Yves; Mailleau, Alexis] BISCEm, FR3503, GEIST, CBRS, 2 Rue Dr Marcland, F-87025 Limoges, France in 2019.0, Cited 44.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
Dihydroporphyrins or chlorins differ from porphyrins only by saturation of a peripheral double bond of the macrocycle. However, this small structural difference leads to a significant increase of the absorption band at approximately 650 nm, which makes them very interesting candidates for photodynamic therapy applications. The reduction of porphyrins bearing two, three or four pyridyl substituents with fin(II) chloride has been developed for the synthesis of dihydroporphyrins in yields of 15-73%. The reduction of 5-(aryl)-10,15,20-tris(2 or 4-pyridyl)porphyrin with fin(II) chloride dihydrate demonstrated good regioselectivity. Porphyrins with one meso-aryl bearing one electron-donating group (EDG) gave 5-aryl-10,15,20-tris(2- or 4-pyridyl)-17,18-dihydroporphyrins in 17-72% yield. Porphyrins with one meso-aryl bearing one or more electron-withdrawing groups (EWG) gave 5-aryl-10,15,20-tris(4-pyridyl)-17,18-dihydroporphyrins or 5-aryl- 10,15,20-tris(4-pyridyl)-7,8-dihydroporphyrins in 15-21% yield and isobacteriochlorin. We have also proven the possibility of functionalizing these compounds to design new regioisomerically pure photosensitizers.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem