Let¡¯s face it, organic chemistry can seem difficult to learn, Recommanded Product: 31106-82-8, Especially from a beginner¡¯s point of view. Like 31106-82-8, Name is 2-(Bromomethyl)pyridine hydrobromide, molecular formula is pyridine-derivatives, belongs to pyridine-derivatives compound. In a document, author is Yamamoto, Keisuke, introducing its new discovery.
Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold
We previously identified dibenzooxepine derivative 1 as a potent PPAR. ligand with a unique binding mode owing to its non-thiazolidinedione scaffold. However, while 1 showed remarkably potent MKN-45 gastric cancer cell aggregation activity, an indicator of cancer differentiation-inducing activity induced by PPAR. activation, we recognized that 1 was metabolically unstable. In the present study, we identified a metabolically soft spot, and successfully discovered 3-fluoro dibenzooxepine derivative 9 with better metabolic stability. Further optimization provided imidazo[1,2-alpha]pyridine derivative 17, which showed potent MKN-45 gastric cancer cell aggregation activity and excellent PK profiles compared with 9. Compound 17 exerted a growth inhibitory effect on AsPC-1/AG1 pancreatic tumor in mice. Furthermore, the decrease in the hematocrit (an indicator of localized edema, a serious adverse effect of PPAR gamma ligands) was tolerable even with oral administration at 200 mg/kg in healthy mice.
If you are hungry for even more, make sure to check my other article about 31106-82-8, Recommanded Product: 31106-82-8.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem