Adding a certain compound to certain chemical reactions, such as: 89978-52-9, Ethyl 2-bromoisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89978-52-9, blongs to pyridine-derivatives compound. Application In Synthesis of Ethyl 2-bromoisonicotinate
A mixture of 1H-indole-3-carbonitrile (0.1 g), 2-bromoisonicotinic acid ethyl ester (0.16 g), potassium phosphate (0.27 g), (1R,2R)-(-)-N,N’-dimethylcyclohexane-1,2-diamine (0.017 g), copper iodide (0.006 g) and toluene (0.7 mL) was stirred at 110C for 38 hours. The insoluble material was removed by filtration, and this filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: ethyl acetate/n-hexane = 10/90 to 66/34) to give the title compound (0.061 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89978-52-9, its application will become more common.
Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP2133332; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem