Related Products of 89978-52-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89978-52-9, name is Ethyl 2-bromoisonicotinate. This compound has unique chemical properties. The synthetic route is as follows.
Example 19; 2-(3-Cyano-4-phenylpyrrole-1-yl)isonicotinic acid ethyl ester; To a solution of 4-phenyl-1H-pyrrole-3-carbonitrile (0.1 g) in toluene (0.70mL) were added 2-bromo-isonicotinic acid ethyl ester (0.19 g), potassium phosphate (0.31 g), (1R,2R)-(-)-N,N’-dimethylcyclohexane-1,2-diamine (0.02 g) and copper iodide (0.007 g) at room temperature, and this mixture was stirred at 110C for 24 hours. The insoluble material was removed by filtration through Celite, and this filtrate was concentrated. This obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/n-hexane = 10/90 – 66/34) to give the title compound (0.066 g).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89978-52-9, Ethyl 2-bromoisonicotinate.
Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP2133331; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem