Adding a certain compound to certain chemical reactions, such as: 829-45-8, Methyl 3-(4-Pyridyl)-3-oxopropanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H9NO3, blongs to pyridine-derivatives compound. HPLC of Formula: C9H9NO3
General procedure: A solution of the amidine 6 (1.1 equiv, 276 mg, 1.23 mmol) and the beta-ketoester 8a (1 equiv, 200 mg, 1.12 mmol) in nBuOH (3 mL) was stirred at 110 C for 18 h. During this time a solid precipitate formed. After cooling to room temperature, the solid was filtered off and air-dried to provide 9a (190 mg, 48%) as a pale yellow solid;
At the same time, in my other blogs, there are other synthetic methods of this type of compound,829-45-8, Methyl 3-(4-Pyridyl)-3-oxopropanoate, and friends who are interested can also refer to it.
Reference:
Article; Large, Jonathan M.; Torr, Jane E.; Raynaud, Florence I.; Clarke, Paul A.; Hayes, Angela; Stefano, Francesca Di; Urban, Frederique; Shuttleworth, Stephen J.; Saghir, Nahid; Sheldrake, Peter; Workman, Paul; McDonald, Edward; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 836 – 851;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem