Application of 161117-83-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 161117-83-5 as follows.
Under a nitrogen atmosphere, a whole batch of compound II in tetrahydrofuran solution, 93.6 g of tetramethylethylenediamine (0.8 mol, 2.0 eq) was added to the reaction flask.Cool to -78 , add 261.1g n-butyl lithium n-hexane solution (0.96mol, 2.4eq) dropwise,After the dropwise addition, the reaction was kept for 2 hours.After the heat preservation is completed, the temperature is controlled to -40 C, 58.9 g of N-N-dimethylformamide (0.8 mol, 2.0 eq) is added, and the mixture is stirred for 30 min.After the reaction is completed, the temperature is controlled at 0-20 C, the pH value is adjusted to 5-7 with 3N hydrochloric acid, the layers are separated, 200g of methylene chloride is added to the aqueous phase, and extraction is performed once.Combine the organic phases, concentrate under reduced pressure until a large amount of solid precipitates, add 300g of n-heptane and steam to a certain volume.Beating and filtering to obtain 79.3g of yellow solid (78% yield in two steps) is compound III.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,161117-83-5, its application will become more common.
Reference:
Patent; Cheng Da Pharmaceutical Co., Ltd.; Shi Yuhua; Qian Wei; Feng Yu; Huang Xing; Dang Junkui; Wang Zhipeng; Dong Changming; Xu Hong; Huang Zongxi; Chen Ye; Shen Huafei; Zhang Jun; (12 pag.)CN110964011; (2020); A;,
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