Electric Literature of 1083057-12-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1083057-12-8, name is tert-Butyl 3-(3-methylpyridin-2-yl)benzoate. This compound has unique chemical properties. The synthetic route is as follows.
The 3-butyl 3-(3-methylpyridin-2-yl)benzoate (1.0 eq.) was dissolved in EtOAc (6 EtOAc). Water (0.3 vol) and hydrogen peroxide urea (3 eq.) were added in that order. Phthalic anhydride (3 equivalents) was then added portionwise to the mixture in solid form at a rate to maintain the temperature in the reactor below 45 C. After the addition of phthalic anhydride was completed, the mixture was heated to 45 C. After stirring for another 4 hours, the heater was turned off. A 10% w/w aqueous Na2SO3 solution (1.5 eq.) was added via an addition funnel. After the addition of Na2SO3 was completed, the mixture was stirred for additional 30 min and the layers were separated. The organic layer was stirred and a 10% wt/wt aqueous Na2CO3 solution (2 eq.) was added. After stirring for 30 minutes, the layers were separated. The organic phase was washed with a 13% w/v NaCl aqueous solution. The organic phase was then filtered and concentrated to give crude 2-(3-(t-butoxycarbonyl)phenyl)-3-methylpyridine-1-oxide (95%) which was used directly in the next step .
According to the analysis of related databases, 1083057-12-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; VERWIJS, MARINUS JACOBUS; ALARGOVA, ROSSITZA GUEORGUIEVA; KAUSHIK, RITU ROHIT; KADIYALA, IRINA NIKOLAEVNA; YOUNG, CHRISTOPHER; (118 pag.)TWI636051; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem