Supramolecular assemblies of new pseudohalide end-to-end bridged copper(II) complex and molecular structural variety of penta and hexa-coordinated metal(II) complexes with hydrazido-based ligand was written by Singh, Yogendra;Patel, R. N.;Patel, S. K.;Jadeja, R. N.;Patel, A. K.;Patel, N.;Roy, H.;Bhagriya, P.;Singh, Rita;Butcher, R. J.;Jasinski, Jerry P.;Herrero, S.;Cortijo, M.. And the article was included in Inorganica Chimica Acta in 2020.SDS of cas: 91-02-1 This article mentions the following:
With an hydrazido-based ligand, C14H13N2O and Cu, Ni metal(II) salts, three new mononuclear [Ni(HL)(NO3)(H2O)]NO3,C14H15N5NiO8 (1), [Cu(HL)(H2O)2].2NO3, C14H17CuN5O4 (2), [Ni(HL)2].2ClO4, C28H30Cl2N6NiO12 (3) and one binuclear end-to-end thiocynate bridged [Cu2(μ-SCN)2(L)2], C30H24Cu2N8O2S2 (4) complexes have been synthesized and characterized by physico-chem. techniques. All of the complexes were structurally characterized using single crystal X-ray diffraction. Complexes 1 and 2 have a penta-coordinated environment around the metal(II) center, whereas complex 3 has a distorted hexa-coordinated geometry. In complex 4 two symmetry related, adjacent copper(II) coordination moieties are joined end-to-end in an unprecedented manner forming a thiocynate bridged, yielding a dicopper entity. The presence of two “sym.” thiocynate bridges with Cu-SCN and Cu-NCS distances of 2.832 Å and 1.925 Å, resp., results in a Cu···Cu distance of 5.503 Å. Binuclear complex, 4 exhibits a weak antiferromagnetic interaction between adjacent copper(II) centers. These copper(II) mononuclear and binuclear complexes have also been studied by X-band EPR. The crystal packing of these new complexes is stabilized by H-bonding, weak intermol. interactions, CH···π and π···π interactions. Electrochem. data (CV and DPV) for the complexes shows MII → MI reduction activity. Electronic spectroscopy and computational features are examined by quantum chem. studies. The inhibitory effect of the complexes were tested on a cell population with IMR 32 (neuroblastoma), MCF 7 (breast cancer), HepG2 (hepatocellular carcinoma), L132 (lung cells) cell lines by MTT assay. Complex 3 showed a prominent cytotoxicity against the all cell lines. Expression levels of the Bax (pro-apoptotic) and Bcl2 (anti-apoptotic) genes were also studied, wherein the genes of interest showed a moderate down regulation after treatment with complexes 1 and 3. Finally, antioxidant superoxide dismutase activity measurements show that the complexes behave as superoxide dismutase mimics. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1SDS of cas: 91-02-1).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 91-02-1