In 2019,Chemistry – A European Journal included an article by Sinha, Narayan; Heijnen, Dorus; Feringa, Ben L.; Organ, Michael G.. SDS of cas: 53939-30-3. The article was titled 《Murahashi cross-coupling at -78 °C: a one-pot procedure for sequential C-C/C-C, C-C/C-N and C-C/C-S cross-coupling of bromo-chloro-arenes》. The information in the text is summarized as follows:
The coupling of organolithium reagents, including strongly hindered examples, with (hetero)aryl bromides at cryogenic temperatures (as low as -78 °C) was achieved with high-reactivity Pd-NHC catalysts to obtain arenes. A temperature-dependent chemoselectivity trigger was developed for synthesis of arenes by selective coupling of aryl bromides in the presence of chlorides. Building on this, a one-pot, sequential coupling strategy was presented for the rapid construction of arenes, amines and thioethers. Importantly, preparation of arenes by one-shot addition of alkyllithium compounds to Pd cross-coupling reactions was achieved, eliminating the need for slow addition by syringe pump. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3SDS of cas: 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 53939-30-3