Sitte, Elisabeth; Twamley, Brendan; Grover, Nitika; Senge, Mathias O. published an article in 2021. The article was titled 《Investigation of the Reactivity of 1-Azido-3-iodobicyclo[1.1.1]pentane under “”Click”” Reaction Conditions》, and you may find the article in Journal of Organic Chemistry.Recommanded Product: 4-Ethynylpyridine The information in the text is summarized as follows:
The bicyclo[1.1.1]pentane (BCP) unit is under scrutiny as a bioisostere in drug mols. We employed methodologies for the synthesis of different BCP triazole building blocks from one precursor, 1-azido-3-iodobicyclo[1.1.1]pentane, by “”click”” reactions and integrated cycloaddition-Sonogashira coupling reactions. Thereby, we accessed 1,4-disubstituted triazoles such as I (R = 1-pyrenyl, Ph, 4-pyridinyl; R1 = H), 5-iodo-1,4,5-trisubstituted triazoles such as I (R = 1-pyrenyl, Ph, 4-pyridinyl; R1 = I), and 5-alkynylated 1,4,5-trisubstituted triazoles such as I (R = 1-pyrenyl, Ph, 4-pyridinyl; R1 = RCC). This gives entry to the synthesis of multiply substituted BCP triazoles on either a modular or a one-pot basis. These methodologies were further utilized for appending porphyrin moieties onto the BCP core. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 4-Ethynylpyridine