In 2002,Organic Syntheses included an article by Smith, Adam P.; Lamba, Jaydeep J. S.; Fraser, Cassandra L.. Application of 138219-98-4. The article was titled 《Efficient synthesis of halomethyl-2,2′-bipyridines: 4,4′-bis(chloromethyl)-2,2′-bipyridine》. The information in the text is summarized as follows:
Silylation of 4,4′-dimethyl-2,2′-bipyridine with LDA followed by chlorotrimethylsilane gave 97% 4,4′-bis(trimethylsilylmethyl)-2,2′-bipyridine, treatment of which with Cl3CCCl3 and CsF in MeCN, gave 91% 4,4′-bis(chloromethyl)-2,2′-bipyridine. Among the 7 other halobipyridines similarly prepared were 98% 5-(chloromethyl)-2,2′-bipyridine 99% 4,4′-bis(bromomethyl)-2,2′-bipyridine. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application of 138219-98-4)
4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application of 138219-98-4