Soczewka, Piotr; Tribouillard-Tanvier, Deborah; di Rago, Jean-Paul; Zoladek, Teresa; Kaminska, Joanna published the artcile< Targeting copper homeostasis improves functioning of vps13δ yeast mutant cells, a model of VPS13-related diseases>, Name: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is CCC2 VPS13A CTR1 cox11 Parkinson Menke Wilson disease; CCC2; CTR1; FET3; VPS13; copper homeostasis; disulfiram; elesclomol; pyrithione; yeast model, neurodegeneration.
Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with Menkes andWilsons diseases, respectivley, and iron imbalance is observed in Parkinsons and Alzheimers diseases. To better understand human diseases, Saccharomyces cerevisiae yeast are used as a model organism. In our studies, we used the vps13δ yeast strain as a model of rare neurol. diseases caused by mutations in VPS13A-D genes. In this work, we show that overexpression of genes encoding copper transporters, CTR1, CTR3, and CCC2, or the addition of copper salt to the medium, improved functioning of the vps13δ mutant. We show that their mechanism of action, at least partially, depends on increasing iron content in the cells by the copper-dependent iron uptake system. Finally, we present that treatment with copper ionophores, disulfiram, elesclomol, and sodium pyrithione, also resulted in alleviation of the defects observed in vps13δ cells. Our study points at copper and iron homeostasis as a potential therapeutic target for further investigation in higher eukaryotic models of VPS13-related diseases.
International Journal of Molecular Sciences published new progress about Alzheimer disease. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Name: 2-Mercaptopyridinen-oxide sodiumsalt.