Related Products of 1008-91-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1008-91-9, name is 1-(Pyridin-4-yl)piperazine. A new synthetic method of this compound is introduced below.
General procedure: A solution of AlMe3 in toluene (1.5 mol equiv., 2 M) was added to the methyl benzoate 16 or 17 (1.0 mmol) dissolved in toluene (3.5 mL) in a round-bottomed flask. The appropriate piperazine (1.4 mol equiv.) was then added, together with an additional volume of toluene (3.5 mL). The reaction mixture was then stirred at RT for 1 h, before being stirred under heating at 110 C for an additional 1 h. The solvent was then removed under reduced pressure. EtOAc (10 mL) was then used to dissolve the residue, after which the organic phase was washed sequentially with aqueous NaHCO3 (sat., 50 mL) and brine (50 mL). The organic layer was dried (Na2SO4), filtered and removed under reduced pressure, resulting in a dark yellow oil. This residue was purified by silica gel column chromatography (90 %EtOAc/MeOH) to obtain the desired products 18 or 19, for which the details are given below.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1008-91-9, 1-(Pyridin-4-yl)piperazine, and friends who are interested can also refer to it.
Reference:
Article; Chakravorty, Santanu; Klein, Hanna F.; Hodson, Luke E.; Rabillier, Matthias; Fang, Zhizhou; Richters, Andre; Pelly, Stephen C.; Rauh, Daniel; Van Otterlo, Willem A.L.; South African Journal of Chemistry; vol. 67; (2014); p. 71 – 79;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem