Reference of 101990-73-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101990-73-2, name is 2-Chloro-4-(chloromethyl)pyridine, molecular formula is C6H5Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-chloro-4-((5-methyl-3-(5- phenylfuran-2-yl)-lH-l,2,4-triazol-l-yl) methyl)pyridine and 2-chloro-4-((3- methyl-5-(5-phenylfuran-2-yl)-lH-l,2,4-triazol-l -yl)methyl)pyridine (100 mg, 0.3 mmol) was treated with 1-methylpiperazine (280 mg, 3 mmol) in DIEA (10 ml), and refluxed overnight. The mixture was cooled, concentrated, treated with H20 (30 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with H20 (1 x 10 mL) and brine (1 x 10 mL), dried over Na2S04, filtered, and concentrated to afford the crude product, which was purified by prep-HPLC (Mobile phase: A = 0.1% NH4OH/H20, B = MeCN; Gradient: B = 60%-95% in 18 min; Column: XBridge (C18, 5um, 30mm x 150mm) to give l-methyl-4-(4-((5- methyl-3-(5-phenylfuran-2-yl)-lH-l,2,4-triazol-l-yl)methyl)pyridin-2-yl)piperazine as a yellow solid (66 mg, 53%) and l-methyl-4-(4-((3-methyl-5-(5-phenylfuran-2- yl)-lH-l,2,4-triazol-l-yl)methyl)pyridin-2-yl)piperazine as a yellow solid (42 mg, 34%). For l-methyl-4-(4-((5-methyl-3-(5-phenylfuran-2-yl)-lH-l,2,4-triazol-l-yl)methyl) pyridin-2-yl)piperazine: MS (ES+) C24H26N60 requires: 414, found: 415 [M+H]+. *H NMR (500 MHz, CDC13) delta 8.14 (d, 7 = 5.1 Hz, 1H), 7.89 – 7.72 (m, 2H), 7.39(t, / = 7.8 Hz, 2H), 7.28 (td, / = 7.4, 1.3 Hz, 1H), 7.04 (d, / = 3.5 Hz, 1H), 6.76 (d, J = 3.5 Hz, 1H), 6.44 – 6.26 (m, 2H), 5.26 (s, 2H), 3.53 (t, J = 5.0 Hz, 4H), 2.48 (t, / = 5.1 Hz, 4H), 2.44 (s, 3H), 2.32 (s, 3H). [0250] For l-methyl-4-(4-((3-methyl-5-(5-phenylfuran-2-yl)-lH-l,2,4-triazol- l-yl)methyl) pyridin-2-yl)piperazine: MS (ES+) C24H26N6O requires: 414, found: 415 [M+H]+. *H NMR (500 MHz, CDC13) delta 8.12 (d, / = 5.1 Hz, 1H), 7.63 – 7.55 (m, 2H), 7.38 (t, 7 = 7.6 Hz, 2H), 7.30 (dd, / = 14.4, 6.9 Hz, 1H), 7.11 (d, 7 = 3.5 Hz, 1H), 6.77 (d, / = 3.6 Hz, 1H), 6.51 – 6.40 (m, 2H), 5.60 (s, 2H), 3.46 (t, / = 5.1 Hz, 4H), 2.45 (s, 3H), 2.43 (t, / = 5.1 Hz, 4H), 2.30 (s, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 101990-73-2, 2-Chloro-4-(chloromethyl)pyridine.
Reference:
Patent; JONES, Philip; DIFRANCESCO, Maria, Emilia; PETROCCHI, Alessia; CARROLL, Christopher, L.; MARSZALEK, Joe; CZAKO, Barbara; JOHNSON, Ryan; THEROFF, Jay; WO2014/31936; (2014); A2;,
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