Adding a certain compound to certain chemical reactions, such as: 107867-51-6, 5-(Trifluoromethyl)pyridine-2,3-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H6F3N3, blongs to pyridine-derivatives compound. Formula: C6H6F3N3
General procedure: Step 1: To a solution of compound 47 (35 mg, 0.097 mmol) in 3% HOAc/DMF (2 mL) wasadded 4, 5-difluorobenzene-1, 2-diamine (28 mg, 0.194 mmol) and potassiumperoxymonosulfate (Oxone, 60 mg, 0.097 mmol). The reaction was stirred at 80C for 16 hr. Thesolution was cooled to ambient temperature and neutralized with K2CO3 (30 mg). The mixturewas patitioned between EtOAc (6 mL) and water (2 mL). The organic phase was isolated andevaporated in vacuum.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,107867-51-6, 5-(Trifluoromethyl)pyridine-2,3-diamine, and friends who are interested can also refer to it.
Reference:
Article; Yu, Yang; Wu, Zhicai; Shi, Zhi-Cai; He, Shuwen; Lai, Zhong; Cernak, Timothy A.; Vachal, Petr; Liu, Min; Liu, Jian; Hong, Qingmei; Jian, Tianying; Guiadeen, Deodial; Krikorian, Arto; Sperbeck, Donald M.; Verras, Andreas; Sonatore, Lisa M.; Murphy, Beth A.; Wiltsie, Judyann; Chung, Christine C.; Gorski, Judith N.; Liu, Jinqi; Xiao, Jianying; Wolff, Michael; Tong, Sharon X.; Madeira, Maria; Karanam, Bindhu V.; Shen, Dong-Ming; Balkovec, James M.; De Vita, Robert J.; Pinto, Shirly; Nargund, Ravi P.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 11; (2019); p. 1380 – 1385;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem