Application of 1122-54-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1122-54-9, name is 4-Acetylpyridine, molecular formula is C7H7NO, molecular weight is 121.14, as common compound, the synthetic route is as follows.
To a mixture of NaH (6.6 g, 165.2 mmol, 60%in mineral oil) in toluene (120 mL) was added dimethyl carbonate (11.2 g, 123.9 mmol) in toluene (40 mL) . Then 1- (pyridin-4-yl) ethanone (5.0 g, 41.3 mmol, 5) in toluene (40 mL) was added dropwise under N 2. The reaction mixture was stirred at 105 for 12 hours. After cooled to RT, the reaction was quenched with 200 mL (water) and HOAc (20 mL) and the mixture was stirred at RT for 20 minutes. Then the mixture was extracted with EtOAc (300 mL*3) . The combined organic layer was dried over Na 2SO 4, filtered and concentrated. The residue was purified by Prep-HPLC (water/acetonitrile = 10%to 90%) to give the title product (3.89 g, 53%, 6) as a brown solid. LC-MS: Rt = 1.20 min, [M+H] + = 180.
The chemical industry reduces the impact on the environment during synthesis 1122-54-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SHANGHAI CHANGCHENGYIYAOKEJI COMPANY LIMITED; XU, Mingyan; (0 pag.)WO2020/1475; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem