Electric Literature of 1202070-39-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1202070-39-0, name is (R)-1-(5-Fluoropyridin-2-yl)ethanamine hydrochloride, molecular formula is C7H10ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step D: N-rrii?Vl-r5-Fluoropyridin-2-vnethyll-3-(5-methylpyridin-2-vn-5-[(R/SV2.2,2- trifluoro- 1 -hvdroxyethvPbenzamide; To a solution of 3-(5-methylpyridin-2-yl)-5-(2,2,2-trifluoro-l- hydroxyethyl)benzoic acid (25 mg, 0.072 mmol) in N^-dimethylformamide (0.7 mL) were added (li?)-l-(5-fluoropyridin-2-yl)ethanamine hydrochloride salt (23 mg, 0.11 mmol), EDC (20.7 mg, 0.11 mmol), HOAT (0.5 M in DMF; 72 muL, 0.036 mmol) and triethylamine (60 muL, 0.43 mmol). The reaction mixture was heated to 60 C. After 3 h, the mixture was cooled to ambient temperature and the solid in the reaction was filtered off. Purification by reverse phase chromatography (C-18, 75% water/ acetonitrile ? 48% water/ acetonitrile with 0.1% trifluoroacetic acid) gave the trifiuoroacetate salt of the title compound. HRMS 434.1484(M+l). 1H NMR (500 MHz, DMSOd6): delta 9.09 (d, J= 7.6 Hz, 1 H); 8.57 (d, J= 8.0 Hz, 2 H); 8.52 (d, J= 3.0 Hz, 1 H); 8.38 (s, 1 H); 8.05 (s, 1 H); 7.98 (d, J= 8.1 Hz, 1 H); 7.78 (dd, J= 8.2, 2.2 Hz, 1 H); 7.70 (td, J= 8.8, 3.0 Hz, 1 H); 7.52 (dd, J= 8.8, 4.5 Hz, 1 H); 7.01 (d, J= 5.6 Hz, 1 H); 5.37-5.31 (m, 1 H); 5.29-5.23 (m, 1 H); 2.37 (s, 3 H); 1.55 (d, J= 7.1 Hz, 3 H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1202070-39-0, (R)-1-(5-Fluoropyridin-2-yl)ethanamine hydrochloride.
Reference:
Patent; MERCK & CO., INC.; WO2009/58298; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem