Synthetic Route of 1206978-11-1, Adding some certain compound to certain chemical reactions, such as: 1206978-11-1, name is 2-Bromo-3-(trifluoromethoxy)pyridine,molecular formula is C6H3BrF3NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1206978-11-1.
A microwave vial was charged with (iS,25)-l-A-(6-fluoro-l,3-beiizothiazol-2- yl)cyclopentane-l,2-di amine hydrochloride (Intermediate 1; 172 mg, 0.60 mmol), molybdenum hexacarbonyl (79 mg, 0.30 mmol), tri-tert-butylphosphonium (0587) tetrafiuoroborate (5 mg, 0.018 mmol), 2-bromo-3-(trifluoromethoxy)pyridine (145 mg, 0.60 mmol), Herrmanns Catalyst (6 mg, 6.41 muetaiotaomicron) and DBU (150 mu, 0.998 mmol) in dry 1,4-dioxane (2.4 ml). The reaction was subjected to microwave irradiation at 125 C for 25 minutes then partitioned between ethyl acetate and water. The organics were washed with water and brine, filtered through a hydrophobic frit and concentrated in vacuo. The crude material was purified by column chromatography (silica, 0 – 100% ethyl acetate / petrol then 0 – 30% methanol /’ ethyl acetate) then further purified by reverse phase preparative HPLC (eluted with acetonitriie / water containing 0.1 % ammonia) to afford the title compound. (0588) 1H NMR (400 MHz, DMSO-6) delta ppm 1.50 – 1.64 (m, 2 H), 1.68 – 1.80 (m, 2 1 1 }.. 2.07 – 2.21 (m, 2 H), 4.13 – 4.23 (m, 1 H), 4.23 – 4.33 (m, 1 H), 6.97 – 7.10 (m, 1 H), 7.26 – 7.37 (m, 1 H), 7.52 – 7.62 (m, 1 H), 7.64 – 7.74 (m, 1 H), 7.90 – 8.03 (m, 1 H), 8.14 – 8.23 (m, 1 H), 8.55 – 8.69 (m, 1 H), 8.92 – 9.02 (m, 1 H) MS ES?: 441
According to the analysis of related databases, 1206978-11-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; FUJIMOTO, Tatsuhiko; ROBINSON, John Stephen; WO2015/124934; (2015); A1;,
Pyridine – Wikipedia,
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