Related Products of 1214328-96-7 ,Some common heterocyclic compound, 1214328-96-7, molecular formula is C7H5BrClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Urea hydrogen peroxide (65.32 g, 347.2 mmol) was added portionwise to a solution of trifluoroacetic anhydride (145.8 g, 694.4 mmol, 96.5 ml_) in dichloromethane (577 ml_) at 0 0C. S-Bromo-e-chloro-pyridine^-carboxylic acid methyl ester (prepared as described in Example 1) (27.18 g, 108.5 mmol) was added to the mixture portionwise and the reaction mixture was stirred at room temperature for 19 h. The reaction was quenched by the addition of water, the phases separated and the organic layer washed with water and saturated aqueous potassium carbonate. The organic layer was dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 3-bromo-6- chloro-pyridine-2-carboxylic acid Lambda/-oxide as a yellow oil. Characterising data for the compound are as follows: 1H NMR (400 MHz1 CD3OD) delta 7.77-7.75 (m, 2H) and 4.01 (s, 3H) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1214328-96-7, its application will become more common.
Reference:
Patent; SYNGENTA LIMITED; WHITTINGHAM, William Guy; HACHISU, Shuji; HOTSON, Matthew Brian; WO2010/149956; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem