Application of 1214329-07-3 ,Some common heterocyclic compound, 1214329-07-3, molecular formula is C8H8BrNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 5-bromo-6-methoxypyridine-2-carboxylic acid methyl ester (2) (1.0 g, 0.00406 mol) in EtOH (10 mL), was added NH2¡¤NH2¡¤H2O (813 mg,0.0162 mol) and the mixture was stirred for 3 h at 70 C, cooled to room temperature, solvents were evaporated, water was added, filtered the reaction mass, to give pure compound (3): Off-white solid; yield: 85 %, m.p.: 188-190 C; 1H NMR (400MHz, CDCl3) delta: 4.02 (s, 3H, OCH3), 4.08 (d, 2H, NH2), 7.65(d, 1H, Ar-H), 7.98 (s, 1H, Ar-H), 8.68 (broad s, 1H, NH);MS: m/z (%) 247.7 [M+2], HPLC purity (99.61 %).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1214329-07-3, Methyl 5-bromo-6-methoxypicolinate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Namani, Vasu; Bharath Kumar Goud; Kumari, Y. Bharathi; Asian Journal of Chemistry; vol. 27; 12; (2015); p. 4579 – 4582;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem