Reference of 614750-81-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 614750-81-1, name is [1,2,4]Triazolo[1,5-a]pyridine-6-carbaldehyde, molecular formula is C7H5N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of [l,2,4]triazolo[l,5-a]pyridine-6-carbaldehyde (2.5 g, 0.0169 mol) in a mixed solvent of THF (40 mL) and iPrOH (10 mL), was added (phenylamino-(2-methyl- pyrimidin-4-yl)-methyl)-phosphonic acid diphenyl ester (7.33 g, 0.0169 mol; see Example l(b) above) and Cs2CO3 (7.26 g, 0.022 mol). It was stirred at room temperature for 48 hours and then treated with 3N HCl (10 mL) for 1 hour. The reaction mixture was then diluted with methyl t-butyl ether and extracted with IN HCl twice. The combined aqueous layers were neutralized with 30percent aqueous KOH to pH of ca. 8, then extracted with ethyl acetate (3x). Organic layers were dried over MgSO4 and concentrated to yield a dark orange oil, which was purified on silica gel column with EtOAc/hexane (4:1) to give l-(2-methyl-pyrimidin-4-yl)-2- [l,2,4]triazolo[l,5-a]pyridin-6-yl-ethanone (4.15 g, 97percent) as a yellow solid. 1H NMR (300 MHz, CDCl3), delta 8.94 (d, IH), 8.62 (s, IH), 8.34 (s, IH), 7.76 (d, IH), 7.75 (s, IH), 7.51 (d, IH), 4.61 (s, 2H), 2.90 (s, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 614750-81-1, [1,2,4]Triazolo[1,5-a]pyridine-6-carbaldehyde.
Reference:
Patent; BIOGEN IDEC MA INC; WO2006/26305; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem