In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1312784-89-6, name is tert-Butyl 1-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridine-5(4H)-carboxylate, the common compound, a new synthetic route is introduced below. SDS of cas: 1312784-89-6
Under nitrogen protection, dissolve 5.0Kg of 1-methyl-6,7-dihydro-1H-imidazo [4,5-C] pyridine-5- (4H) -carboxylic acid tert-butyl ester in 30L of tetrahydrofuran and stir, The temperature of the dry ice ethanol bath is reduced to -60 ,Slowly add 16.9L n-butyl lithium n-hexane solution (2.5mol / L),Control the reaction temperature not to exceed -50 C, keep the temperature at -50 C ~ -60 C for 1 hour after the addition is completed, pass in 2.8 kg of dried carbon dioxide gas, keep the temperature not to exceed -40 C, and increase the temperature to 20 after completion Reaction at -25 C for 2 hours; add 1mol / L dilute hydrochloric acid aqueous solution to adjust PH = 2-3, stir for 10 minutes, separate layers, extract the aqueous layer with 80L ethyl acetate, combine the organic layers, wash with 30L saturated brine, without Dry over sodium sulfate, filter and concentrate to give an oily liquid 1-methyl-6,7-dihydro-1H-imidazo [4,5-C] pyridine-5- (4H) -carboxylic acid tert-butyl ester-2- Carboxylic acid 5.2Kg, purity by HPLC detection was 98.2%, yield was 87.7%.
The synthetic route of 1312784-89-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou Laikeshide Pharmaceutical Co., Ltd.; Gao Jian; Yu Jurong; (8 pag.)CN110950886; (2020); A;,
Pyridine – Wikipedia,
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