As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 151509-03-4, name is Imidazo[1,5-a]pyridine-8-carbaldehyde, molecular formula is C8H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Imidazo[1,5-a]pyridine-8-carbaldehyde
To a solution of imidazo[1,5-a]pyridine-8-carbaldehyde (60 mg, 0.41 mmol) in H20 (10 mL) was added 1-cyclohexylethan-1-one (52 mg, 0.41 mmol) and NaHCO3 (18 mg, 0.21 mmol),the reaction was warmed to reflux and stirred at for about 40 hours. Extracted with CH2C12 (3*10 mL), the combined organic phases were washed with sat. NaC1 (5 mL), dried overanhydrous Na2504, filtered, concentrated, the crude product was purified by Pre-TLC (DCM:MeOH = 15:1), got the product (10 mg, 9.6%) as a pale yellow solid. MS (ESI) m/e [M+1] 255.1.
With the rapid development of chemical substances, we look forward to future research findings about 151509-03-4.
Reference:
Patent; BEIGENE, LTD.; WANG, Hexiang; ZHANG, Guoliang; GUO, Yunhang; REN, Bo; WANG, Zhiwei; ZHOU, Changyou; (219 pag.)WO2016/161960; (2016); A1;,
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