Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153034-80-1, name is 2-Fluoro-4-iodo-3-picoline. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 153034-80-1
A mixture of the product from the previous step (22 g, 93 mmol), Pd(OAc)2 (2.2 g, 9.8 mmol), l ,l’-bisdiphenylphosphino ferrocene (5.1 g, 9.2 mmol), and NaHC03 (46.7 g, 556 mmol) in MeOH (1 L) was stirred overnight in a CO atmosphere at 80 C. The mixture was cooled to room temperature, then water and sat. aq. (0516) NaHC03 solution were added. The mixture was then extracted with EtOAc. The organic layers was washed with saturated brine, and then dried over anhydrous sodium sulfate. The mixture was filtered and concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (Petroleum ether : EtOAc = 4: 1) to give the title compound as a colorless oil (12 g, 77%).MS (ES+) C8H8FN02 requires: 169, found: 170 [M+H]+.
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Reference:
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; JONES, Philip; CROSS, Jason; BURKE, Jason; MCAFOOS, Timothy; KANG, Zhijun; (154 pag.)WO2019/213318; (2019); A1;,
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