Application of 156072-84-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 156072-84-3 as follows.
(5-chloro-3-methylpyridin-2-yl)methanamine5-chloro-3-methylpyridine-2-carbonitrile (0.50 g; 3.28 mmol; 1.00 eq.) was dissolved in 7M ammonia/methanol (16 ml) and ethanol (16 ml) with Raney Ni which had been rinsed with ethanol 3×. The reaction was charged with H2 and stirred vigorously. After 21 h, the reaction was filtered through Celite, evaporated to a reddish-blue residue of (5-chloro-3-methylpyridin-2-yl)methanamine which was carried on without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,156072-84-3, its application will become more common.
Reference:
Patent; Global Blood Therapeutics, Inc.; Li, Zhe; Xu, Qing; Yu, Chul; Yee, Calvin; Gwaltney,, II, Stephen L.; Metcalf, Brian W.; Richards, Steven; Lardy, Matthew A.; Setti, Lina; Sham, Hing; US2015/315198; (2015); A1;,
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