Some scientific research about 1597-32-6

Application of 1597-32-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1597-32-6, name is 2-Amino-6-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Compound 20: 1-(4-Fluorophenyl)-/V-(6-fluoro-2-pyridinyl)-5-methyl-1H-1 ,2,3-triazole- 4-carboxamide; To a solution of 6-fluoro-2-pyridinamine (0.092 g, 0.822 mmol) in dry 1 ,4-dioxane (1 ml) was added dropwise trimethylaluminium (0.401 ml, 0.802 mmol) (2M solution in toluene). The solution was stirred at room temperature for 30 min. Then a solution of ethyl 1-(4-fluorophenyl)-5-methyl-1 H-1 ,2,3-triazole-4-carboxylate (Intermediate 2) (0.05 g, 0.201 mmol) in dry 1 ,4-dioxane (1 ml) was added at room temperature and the reaction was heated to 100 0C for 1.5 hours. The reaction was cooled to room temperature, quenched cautiously with water (0.06 ml), and stirred at room temperature for 10 min. Then, sodium sulphate (0.25 g) was added to bind the water and the mixture was stirred vigorously for 5 min. Dichloromethane was added and the mixture was stirred for an additional 10 min at room temperature. The solution was filtered and the solid was washed with dichloromethane. The filtrate was evaporated to afford a residue. The residue was partially dissolved in methanol, filtered and the solid washed with diethyl ether to afford a the title compound (44.5%); MH+= 316; 1HNMR (DMSO, 400 MHz): 2.57 (3H s), 6.96 (1 H m), 7.53 (2H t), 7.76 (2H m), 8.07 (2H m), 10.22 (1 H s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1597-32-6, 2-Amino-6-fluoropyridine.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/115486; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem