Reference of 173999-23-0 ,Some common heterocyclic compound, 173999-23-0, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Intermediate 21A. N-((5-bromopyridin-2-yl)methyl)-3,4-dichlorobenzamide[00211] 3,4-Dichlorobenzoic acid (0.50 g, 2.6 mmol), (5-bromopyridin-2- yl)methanamine (0.490 g, 2.62 mmol) and PyBOP (1.5 g, 2.9 mmol) were combined in dimethylformamide (10 mL) and treated with diisopropylethylamine (1.4 mL, 7.9 mmol). The reaction was stirred at rt for 2 h, concentrated and the residue purified on flash chromatography (4 g cartridge, 0 to 100 % ethyl acetate/hexanes) to afford 0.52 g of Intermediate 21 A (55% yield) as a white solid. LC/MS (HPLC Method M): RT = 2.00 min, (M+H)+ = 360.8. -bromo-3 -(3 ,4-dichlorophenyl)imidazo [ 1 ,5-a]pyridine
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,173999-23-0, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; QIAO, Jennifer, X.; FINLAY, Heather; JIANG, Ji; LLOYD, John; HU, Carol Hui; PI, Zulan; TORA, George, O.; NEELS, James; HANGELAND, Jon, J.; FRIENDS, Todd, J.; WO2013/48928; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem