Adding a certain compound to certain chemical reactions, such as: 17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 17570-98-8, blongs to pyridine-derivatives compound. SDS of cas: 17570-98-8
2-Bromo-1-(pyridin-2-yl)ethanone hydrobromide 8a(20.0 g, 71.1 mmol) and K2CO3 (14.8 g, 107 mmol) were suspended in acetone (100 mL), andthe suspension was stirred at room temperature for 1.5 hr. To a solution of ethyl cyanoacetate (60.4 g, 534 mmol) in acetone (100 mL) was addedK2CO3 powder (29.6 g, 214 mmol), and the mixture was stirred at 45C for 1 hr. To this mixture was added dropwise the suspension obtained earlier by small portions at 45C, and the resulting mixture was stirred at 45C for 3 h, filtered after cooled to room temperature, and then concentrated under reduced pressure. The residue was taken up withEtOAc, washed with H2O and brine, dried over anhydrous MgSO4, and concentrated under reduced pressure. To the obtained oil was added 4 mol/L HCl/EtOAc (250 mL) and the mixture was stirred at 60 C for 3 h, and concentrated under reduced pressure. A solution ofNaHCO3 was added to the residue and the mixture was extracted with EtOAc, washed with brine, dried over anhydrous MgSO4,and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/EtOAc = 4/1), then added dropwise 4 mol/L HCl/EtOAc (20 mL) after dissolved in EtOAc (20 mL), concentrated under reduced pressure, and crystalized from EtOAc to yieldcompound 10a (3.08 g, 15%) as a colorless solid: 1H-NMR (DMSO-d6)d 1.30 (3H, t, J=7.0 Hz), 4.25 (2H, q, J=7.0 Hz), 7.48-7.54 (2H, m), 8.13-8.19 (2H, m), 8.61-8.63 (1H, m), 13.47 (1H, br), 1H not detected.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide, and friends who are interested can also refer to it.
Reference:
Article; Nishida, Haruyuki; Arikawa, Yasuyoshi; Hirase, Keizo; Imaeda, Toshihiro; Inatomi, Nobuhiro; Hori, Yasunobu; Matsukawa, Jun; Fujioka, Yasushi; Hamada, Teruki; Iida, Motoo; Nishitani, Mitsuyoshi; Imanishi, Akio; Fukui, Hideo; Itoh, Fumio; Kajino, Masahiro; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3298 – 3314;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem