Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 630395-95-8, name is 1H-Pyrrolo[3,2-c]pyridine-2-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1H-Pyrrolo[3,2-c]pyridine-2-carbaldehyde
To a solution of lH-pyrrolo[3,2-c]pyridine-2-carbaldehyde (3.24 g, 22.19 mmol) in MeOH at 0C under argon is added sodium cyanide (5.44 g, 111 mmol) and manganese dioxide (9.65 g, 111 mmol). The reaction mixture is stirred for 5h after which time it is filtered through Celite and diluted with EtOAc (500mL). The organic layer is washed with water (2x), brine, dried over sodium carbonate, filtered and concentrated to yield 3.27 g ( 84%) of desired product. 1H NMR (DMSO-dtf, 300 MHz) delta 12.3 (bs, 1H), 9.0 (s, 1H), 8.3 (d, 1H), 7.4 (d, 1H), 7.3 (s, 1H), 4.0 (s, 3H). LCMS m/z 177 (M+H).
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Reference:
Patent; SANOFI; CHOI-SLEDESKI, Yong Mi; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng; WO2011/78984; (2011); A1;,
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