With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109306-86-7, name is 2-(2-Bromophenyl)pyridine, molecular formula is C11H8BrN, molecular weight is 234.09, as common compound, the synthetic route is as follows.Application In Synthesis of 2-(2-Bromophenyl)pyridine
Compound 152-3 6.3g (26.86mmol) and sodium azide 3.49 g (53.72mmol), palladium acetate 904mg (4.24mmol),Cerium (IV) sulfate, 17.8g (53.72mmol), Iron (II) chloride 871mg (5.66mmol) was dissolved in 100mL DMSO and stirred at 100C for 79 hours. After the reaction was completed, extracted with ethyl acetate and H2O, separation and purification by column chromatography using Hex / EA to give the title compound 152-2 2.9g (43%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,109306-86-7, 2-(2-Bromophenyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; HEESUNG MATERIAL CO., LTD; KIM, JI-HEE; KIM, YOUNG WOO; LEE, JIN WOO; UHM, SONG JIN; LEE, JU DONG; (45 pag.)KR2015/74833; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem