Related Products of 13534-99-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13534-99-1, name is 2-Amino-3-bromopyridine. A new synthetic method of this compound is introduced below.
The compound 14-1 (200 mg) was dissolved in a mixed solvent of tetrahydrofuran (1.2 ml) and triethylamine (7 ml). Ethynyl (trimethyl) silane (227 mg) , copper (I) iodide (8.8 mg) and dichloropalladium- triphenyl phosphine (32.5 mg) were added and the mixture was sealed in a tube. After stirring the mixture at 900C for 22 hours, the reaction mixture was added to water to terminate the reaction. The aqueous layer was extracted with ethyl acetate, and the organic layer was washed with brine. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The resulting crude product was purified by silica gel column chromatography to obtain the title compound (244 mg) . IH NMR (400 MHz, CDCl3) (ppm) : 0.26 (s, 9H), 5.08 (br. s., 2H), 6.62 (br. s., IH), 7.54d, J=7.2 Hz, IH), 8.05 (br. s. , IH) .
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13534-99-1, 2-Amino-3-bromopyridine, and friends who are interested can also refer to it.
Reference:
Patent; Eisai R&D Management CO., LTD.; MOTOKI, Takafumi; KANEKO, Toshihiko; YAMAMOTO, Noboru; KHAN, Afzal; WO2010/13794; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem